FBXW7 and cancer: Next, to check if FBW7 stabilization alone would sensitize cancer cells and mimic TRIP12 deletion, we used lentivirus-mediated overexpression of wildtype and K404/412R FBW7 (2R) mutant in HCT116FBW7−/− cells which are otherwise resistant to Taxol (Figure 5A) [6,17].