In another study from the same group, the authors performed a high-throughput CRISPR/Cas9 genetic screen to identify modulators of cell fate in the context of resistance to BRAF inhibition in melanoma cells and they found that inactivation of different factors, including DOT1L, LATS2, and BRD2, can modify the proportion of cells primed to become DTP [98]. The gene discussed is BRAF; the disease is melanoma.