It has been well established that BRAF p.V600E mutation drives the activation of the MAPK signaling pathway and that BRAF is frequently mutated in different cancer types, including leukemia, melanoma, thyroid carcinoma, colorectal adenocarcinoma, glioblastoma, and non-small-cell lung cancer [23,24]. This evidence concerns the gene BRAF and colorectal adenocarcinoma.