ICC-specific molecular alterations were disclosed by Zou et al. with 25 significantly mutated genes and eight potential driver genes (TP53, KRAS, IDH1, PTEN, ARID1A, EPPK1, ECE2, and FYN) affecting three important pathways (KRAS/PI3K; p53-cell cycle signaling and TGFß/SMAD-signaling) in ICC. Here, PIK3CA is linked to intrahepatic cholangiocarcinoma.