In addition to CTC detection, great effort is invested in the detection of hepatocellular carcinoma with cell-free DNA (cfDNA) focused on the total amount of DNA [208,209,210,211,212,213,214,215], certain mutational patterns including TERT, TP53, CTNNB1, AXIN1, and other genes [216,217,218,219] and epigenetic methylation patterns [220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239,240]. Here, TP53 is linked to hepatocellular carcinoma.