EGFR and cancer: As described in the above section, The role of ALDH1A3 in multiple drug resistance section, transcriptional ALDH1A3 upregulation in cancer has been connected to histone epigenetic modification of its promoter [43], indirect upregulation through EGFR [80], or STAT3-NF-kB [69], and the activity of transcription factor CEBPβ [69].