Interestingly, in HCC cell lines such as HUH7, the human embryonic kidney such as HEK293T and human prostate cancer cells such as PC3, primary human dermal fibroblasts such as HDFa, human ovarian carcinoma such as OVCAR3, and human glioblastoma cells such as ADF, a key role of the RAN/RANBP1/RANGAP1 system under SGK1 kinase regulation, in controlling the export of pre-miRNAs, was demonstrated [28]. The gene discussed is RANBP1; the disease is hepatocellular carcinoma.