RAN and ovarian carcinoma: By an enriched patient cohort analysis for ovarian cancer, has been demonstrated that levels of cytoplasmic RAN were significantly higher in HG (high-grade tumors, poorly differentiated) tumors compared to LG (low-grade) tumors; concomitantly, the cytoplasmic staining intensity of RANBP1, Importin beta and nuclear localization of RCC1 were significantly increased in HG versus LG tumors.