RANBP1 and neoplasm: An enrichment of the G2M checkpoint, Wingless and Int-1 (Wnt)-dependent cell signaling, and DNA repair pathways was documented in RANBP1 high-expression phenotype by means of GSEA analysis, which also demonstrated that RANBP1 was strongly over-expressed in the tumor-infiltrating lymphocyte compartment (tumor micro-environment), with particular regard to the (Th1) T helper cells component [48].