SGK1 and colon carcinoma: Already in the same p53 wild type colon carcinoma cell samples, it had been demonstrated that the over-expression of SGK1 consistently corresponded to the over-expression of RANBP1, verified by two-dimensional and mass spectrometry approaches, and that conversely, the gene silencing of SGK1 corresponded to the down-regulation of RANBP1 expression.