NR4A1 and breast carcinoma: There is evidence that an increased level of whole body fat measured by dual-energy X-ray absorptiometry in women with a normal BMI is associated with an elevated risk of breast cancer with an adjusted hazard ratio of 1.89 (95% CI, 1.21–2.95) for all invasive breast cancer and 2.21 (95% CI, 1.23–3.67) for hormone-receptor positive breast cancer; there is also a 56% increased risk of developing hormone receptor-positive breast cancer per 5 kg increase in trunk fat [81].