TNF and neoplasm: Moreover, upon SKI-II treatment, we observed a significant downregulation of Arg1 expression in the RAW264.7 cells co-cultured with all the tumor cell lines tested (Figure S3I), accompanied by increased gene expression of the M1 marker Tnfα (Figure S3J) and IL-6 cytokine level in the cell-free supernatant of RAW264.7 cells (Figure S3K).