A combination of celecoxib and doxorubicin resulted in cell cycle arrest at the G1 phase of colon tumoral cells (HCT116), and in combination with ibuprofen and cisplatin in lung adenocarcinoma cells (A549), ibuprofen demonstrated to translocate the Bax protein to mitochondria by inhibiting heat shock protein 70 (Hsp70), facilitating cisplatin-mediated Bax activation, leading to Apaf-1 activation followed by the activation of cytochrome-c and the phosphorylation of caspase-9, resulting in the apoptotic cell death of A549 cells. This evidence concerns the gene BAX and lung adenocarcinoma.