The cumulative HCC occurrence rate in the high serum TSP-2 group was 7.6% at 2 years and 9.4% at 4 years, while the cumulative HCC occurrence rate in the low serum TSP-2 group was 1.0% at 2 years and 3.3% at 4 years (Figure 5). The gene discussed is THBS2; the disease is hepatocellular carcinoma.