The serum TSP-2 levels were significantly higher in the patients with F3-4 stages than in the patients with F0-2 stages (Figure 2A) and showed a significant positive association with serum hyaluronic acid (HA) levels, a well-known fibrosis marker (Figure 2B, Supplementary Table S1), suggesting that serum TSP-2 levels reflect liver fibrosis. Here, THBS2 is linked to Hepatic fibrosis.