A high throughput analysis of the cytokine secretion of GFP-RPMI8226 cells showed that the co-culture of MM with mCherry-HS5 cells resulted in the increased secretion of critical cytokines known to contribute to stroma-mediated drug resistance: IL-6, FGF-b, G-CSF, HGF, IL-10, IL-1RA, IL-8, MCP-1, MIG, and VEGF (Figure 3). This evidence concerns the gene CXCL8 and Miyoshi myopathy.