S1PR2 and diffuse large B-cell lymphoma: Similarly, mutations in GNA13 (the gene encoding Gɑ13), S1PR2, or P2RY8—found in GCB-DLBCL patients—have been demonstrated to cause the dissemination of germinal center B-cells (and in the case of P2RY8 mutations, also enhancing cell growth), hence also leading to germinal center B-cell-derived lymphoma [68].