Inversely, the absence of key molecules associated with a highly efficient anti-tumor immune response (IFNG, IL12A and IL12B, IL18, TNF, GNLY, KLRC2, KLRC3,...) suggested that the cytotoxic potential of infiltrated immune cells was not totally unleashed despite expression of immune cell activation markers (GZMA, GZMB, GZMK, PRF1, CD8A, NKG7, STAT1, IRF1, TARP, KLRK1, PTPRC, CCL5, IL2RG, IL2RB, LCK, PIK3CD, CD69, CD52, CD53, TAP1,...) (Table S4). Here, IL18 is linked to neoplasm.