In addition to human orthologs previously identified as playing key roles in OSCC, p63 signaling, and other cancers, namely, FAT2, K14, and PERP, we identified several novel regulators, including Cotl1, Bcam, Adipor2, and Wnt7b, (Figure 6A) [54,55,56,57,58]. This evidence concerns the gene KRT14 and cancer.