TF and neoplasm: On the other hand, several mutually exclusive relationships were observed: “NPM1” mutations were highly exclusive with “myeloid TFs” (p < 0.001), “Spliceosome–genes” (p < 0.001), and “chromatin–modifying” (p < 0.001); mutations in “Spliceosome–genes” were highly exclusive with “TF fusions” (p < 0.001) and remarkably, the “Tumor suppressor–genes” category was highly exclusive with all other functional categories (p < 0.001) (Figure 2).