In contrast FLT3 (p < 0.001), NPM1 (p < 0.001), DNMT3A (p = 0.032), NRAS (p < 0.01), PTNP11 (p < 0.001) and WT1 (p < 0.001), were frequently mutated in young AML. This evidence concerns the gene NPM1 and acute myeloid leukemia.