Several clinical features are commonly accepted to increase the likelihood of pCR: low carcinoembryonic antigen (CEA) [27,28,29,30], small tumor size [31,32], low tumor/nodal stage [33], low histologic grade [33], small circumferential tumor extent [34], high hemoglobin levels [27,34], and a low neutrophil-to-lymphocyte ratio [35]. Here, CEACAM5 is linked to neoplasm.