RUNX1 and acute lymphoblastic leukemia: Childhood BCP-ALL is characterized by the heterogeneous occurrence of genetic abnormalities and the most common genetic aberrations, which are responsible for 70 to 75% of cases of this disorder, including ETV6::RUNX1, hyperdiploidy, hypodiploidy, TCF3::PBX1, BCR::ABL1, and KMT2A subtypes.