TP53 and ovarian carcinoma: Additionally, in the NCT01357161 trial examining whether adavosertib/AZD1775 could enhance the treatment efficacy of carboplatin/paclitaxel chemotherapy in women with p53-mutated, platinum-sensitive ovarian cancer [31], a modest clinical benefit of adavosertib/AZD1775 was observed by improving PFS (7.9 months vs. 7.3 months; hazard ratio: HR, 0.63).