Another Wee1 inhibitor, adavosertib (AZD1775/MK-1775), also enhances the cytotoxic effects of several DNA-damaging agents (5-FU, pemetrexed, doxorubicin, camptothecin, mitomycin C) specifically in p53-mutated colorectal cancer cells, while it shows little effect on 5-FU-induced cytotoxicity in wtp53 colon cancer cells [114]. Here, TP53 is linked to colonic neoplasm.