TP53 and cancer: PRIMA-1 was shown to restore the p53’s sequence-specific DNA-binding and growth-suppressing activities in multiple cancer cell lines with different p53 mutants, including R110L, V157F, R175H, L194F, R213Q/Y234H, G245V, R248Q, R273C, R273H/P309S, R280K, and R282W.