The overexpression of EZH2 and elevation of H3K27me3 in solid cancers, including breast, gastric, endometrial, ovarian, melanoma, bladder, kidney, colorectal, and lung cancers, as well as hematological malignancies such as T-cell and B-cell lymphomas [22,23]. Here, EZH2 is linked to B-cell non-Hodgkin lymphoma.