Moreover, in cases of single-gene TERT promoter mutations, when there are no worrisome clinicodemographic features (e.g., young age or family history of thyroid cancer), one could consider limited treatment with hemithyroidectomy and close observation after shared decision making (i.e., a thorough discussion of treatment options and their benefits and harms with a patient based on best available evidence and a consideration of the patient’s preferences). This evidence concerns the gene TERT and thyroid cancer.