Another report showed that MPC1 is downregulated in pancreatic cancer cells, and further knockdown of MPC1 resulted in a spindle-like shape, in expression changes of epithelial–mesenchymal transition (EMT) markers such as E-cadherin and fibronectin, as well as in the acquisition of a migratory phenotype. The gene discussed is MPC1; the disease is familial pancreatic carcinoma.