As for the prognostic role of CC genes, the analysis of Cancer Genome Atlas (TCGA) data reported that the overexpression of PER1-3, CRY2, CLOCK, NR1D2, and RORα, as well as the under-expression of TIMELESS and NPAS2, were correlated with longer survival in patients with RCC [33]. The gene discussed is CRY2; the disease is renal cell carcinoma.