MAP4K4 and glioblastoma: In order to better understand the invasion processes of glioblastoma, Prolo Laura M et al. first introduced the large-scale use of CRISPR/Cas9 for screening of loss of function, which aimed at screening genes that could promote tumor cells invading normal tissues, and they found MAP4K4 to be a new potential target for constraining the invasion of glioblastoma [52].