Although clinicopathological factors were not significantly associated with high IL-7R expression levels, histological grade (p = 0.088), depth of tumor invasion (p = 0.075), lymphatic vessel invasion (p = 0.081), blood vessel invasion (p = 0.053), and lymph node metastasis (p = 0.053) tended to be correlated with IL-7R expression in ESCC patients (Table 1). This evidence concerns the gene IL7R and metastatic malignant neoplasm in the lymph nodes.