Knockdown of IL-7R also reduces the growth of non-small cell lung cancer and hepatitis B virus-related hepatoma cells due to a decrease in the expression of cell cycle-related protein Cyclin D1 [41,42], and induces the apoptosis of non-small cell lung cancer via the downregulation of anti-apoptosis-related protein Bcl-2 [43]. This evidence concerns the gene CCND1 and hepatocellular carcinoma.