We assumed that weight loss and decreasing one’s BMI lowers CRC risk for those with a MLH1 PV and lowers endometrial cancer risks for females with a PV in any LS gene with an endometrial cancer association, and we assumed this risk reduction corresponds to the same HR and OR listed in the Movahedi and Trentham-Dietz studies for increases in BMI and weight, respectively. This evidence concerns the gene MLH1 and endometrial cancer.