MSH2 and gastric cancer: For example, gastric cancer may have significantly increased risk for carriers of PMS2 PVs but based on the lower prevalence of PMS2 PVs and less published literature on PMS2, as compared to the other LS genes, we can only estimate ACPs for gastric cancer that are associated with MLH1, MSH2, and MSH6 by age, sex, and gene [1,3].