Bai et al. found that the overexpression of SFRP2 inhibited CRC cell proliferation and promoted apoptosis [49], while several other studies have found a significantly higher expression of SFRP2 in metastatic tumors (including osteosarcoma, breast cancer, and malignant melanoma) [50,51,52]. This evidence concerns the gene SFRP2 and metastatic neoplasm.