Regarding the differential role of TIM-3 expression in TILs with different tumor locations (stromal and intra-tumoral) and in cancer cells, an association between a higher TIM-3+ expression in iTILs and poor clinicopathological features has been reported [37], with similar associations reported for higher frequencies of sTILs-TIM-3+. The gene discussed is HAVCR2; the disease is neoplasm.