HAVCR2 and breast carcinoma: Thus, in this study, our main goals were to evaluate the TIM-3 expression in TILs with different tumor-related locations (stromal and intra-tumoral) and in cancer cells, to compare the serum TIM-3 levels of cats with mammary carcinoma with those of healthy controls, and to identify putative mutations in the feline TIM-3 gene.