In contrast with the previous findings reported in human breast cancer, our results suggest an association between the TIM-3 expression in iTILs and in tTILs and a benign tumoral behavior, including lower tumor size (p = 0.037; p = 0.041) and tumor stage (p = 0.035) and a less frequent metastatic disease (p = 0.010) and tumor recurrence (p = 0.013). This evidence concerns the gene HAVCR2 and breast cancer.