As reported in Table 2, viral etiology of the underlying liver disease (p < 0.0001), Child-Pugh score (p < 0.0001), AFP > 400 UI/mL (p = 0.01), BCLC stage (p = 0.001), and ECOG PS (p = 0.02) resulted as significant predictors of OS in univariate analysis. This evidence concerns the gene AFP and liver disorder.