Many intracellular signaling mediators, including mitogen-activated protein kinases (MAPKs), phosphatidylinositol-3-kinase (PI3K)/Akt, and small cytoplasmic GTPases, are involved in cytoskeleton dynamics that may affect migration; invasion; and, ultimately, the metastatic evolution of solid cancers, including HCC [33,34,35,36,37,38,39]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.