FHIT and cancer: For example, specific hypomethylation was found in the promoter region of nine genes involved in critical cellular pathways (e.g., regulation of cell cycle progression, DNA repair complex) deregulated during cancer development, including hMLH1, MGMT, fragile histidine triad diadenosine triphosphatase (FHIT), adenomatous polyposis coli promoter 1A (APC1A), retinoic acid receptor beta (RARβ), and E-cadherin (E-cad), among the low-grade TMs (types A/AB/B1).