MGMT and carcinoma: For example, it has been observed that the frequency of methylation of secreted protein acidic and cysteine rich (SPARC), death-associated protein kinase (DAPK), CDKN2A, MGMT, and hyperpigmentation, progressive, 1 (HPP1) genes increased according to the histological type of thymomas with the highest peak in carcinomas, particularly for what concerns MGMT methylation, similarly to what has been reported before [95,97].