EPAS1 and nonpapillary renal cell carcinoma: Finally, several of the included studies deepened the association among PSMA-targeting radiopharmaceuticals uptake and WHO/ISUP grade, VEGFR-2/PDGFR-β expression, and HIF-2α expression, reporting that PSMA-targeting PET/CT might be a valuable instrument for discriminating the presence of these pathological features in ccRCC patients [33,36,37].