AFP: alpha-fetoprotein; VEGF-A: vascular endothelial growth factor-A; Ang2: angiopoietin-2; SNP: single nucleotide polymorphism; VEGFR: vascular endothelial growth factor receptor; KDR: kinase insert domain receptor; PD-(L): programmed death-(ligand); TPS: tumor proportion score; CPS: combined positivity score; CTNNB: catenin beta; TMB: tumor mutational burden; IFN-y: interferon-gamma; RNA: ribonucleic acid; TCR: T-cell receptor; CD: cluster of differentiation; CXCR: chemokine receptor; NLR: neutrophil-to-lymphocyte; GPC3: glypican-3. The gene discussed is IFNG; the disease is neoplasm.