Cancers with related tissue origin were clustered together, exhibiting similar IRP expression patterns, including central nervous system cancer (LGG and GBM), genitourinary cancer (KIRC, KIRP, KICH, BLCA, PRAD, and TGCT), thoracic cancer (LUAD, LUSC), gynecologic cancer (OV, UCEC, CESC, and UCS) and Core gastrointestinal cancer (ESCA, STAD, COAD and READ). Here, WNT2 is linked to thoracic cancer.