Genetic studies revealed specific changes in cases of PM of RCC and a lack of loss of 9p and 14q, which are otherwise specific gene mutations at the onset of generalization, a low weight genome instability index, and a low rate of PAB1 and a high rate of BPRM1 alterations, which signal a more favourable course. The gene discussed is PABPC1; the disease is renal cell adenocarcinoma.