DROSHA and neoplasm: The expression levels of miRNA machinery components such as DROSHA and DICER1 are suppressed in cancer and associated with advanced tumor stage and poor clinical outcomes [20,21]; therefore, studying the genes involved in miRNA biogenesis could provide a comprehensive insight into the spatial perturbation along the signaling pathway and help identify the putative vital players in the miRNA machinery system that may function as promising therapeutic targets for cancer.