HBP1 and cancer: Based on the HaploReg v4.1 online tool for variant annotations (https://pubs.broadinstitute.org/mammals/haploreg/haploreg.php), DROSHA (A > G; rs10719) variant can alter HMG box protein 1 (hbp1) motif sequence, a transcription factor, and a potent cell cycle inhibitor in normal and cancer cells [90].