Pooling the data from 45 articles, our results reveal the association of DROSHA (A > G; rs10719), DGCR8 (G > A; rs417309), RAN (A > G; rs3803012), and GEMIN3 (C > A; rs197414) with a 19–93% higher susceptibility to overall cancer. This evidence concerns the gene DGCR8 and cancer.