KPNA2 and neoplasm: They also showed that expression of karyopherin subunit alpha 2 on CAFs, as a protein involved in the nucleocytoplasmic transport pathway for a variety of tumor-associated proteins and representing one of the neoantigen-presenting CAF-specific markers, influenced tumorigenesis and metastasis of lung cancer cells in a murine model, suggesting that CAF subtype markers may offer therapeutic targets in the tumor microenvironment.