Furthermore, miR-210 in the exosome secreted by CAFs was taken up by NSCLC cells and promoted EMT by targeting upstream frameshift 1, a key factor in a variety of RNA decay pathways, and activating the phosphatase and tensin homolog (PTEN)/PI3K pathway in cancer cells, thereby promoting NSCLC migration and invasion [69]. Here, PTEN is linked to non-small cell lung carcinoma.