CD8A and neoplasm: CAFs cross-present antigens complexed with major histocompatibility complex class I to antigen-specific CD8+ T cells to directly contribute to the suppression of antitumor T-cell responses in an antigen-specific, antigen-dependent manner via PD-L2 and CD95 (known as FAS) ligand engagement, suggesting that CAFs play a role in immunosuppressive activity within the tumor microenvironment by a mechanism dependent on immune checkpoint activation [86].