CXCL12 and cancer: Activated CAFs produce higher amounts of stromal cell-derived factor 1 (SDF-1) than LNFs, and SDF-1 facilitates cancer cell proliferation and chemoresistance via the CXC chemokine receptor 4 (CXCR4)-mediated signaling pathway, which involves NF-κB and B-cell lymphoma-extra large [48].