We continued to analyze the genetic alterations from sample subtypes and found that c-Met/GSK3β/MYC/CCND1 were more altered in COAD chromosomal instability (CIN) and in microsatellite instability (MSI) and had higher numbers of mutations and amplifications in CRC tissues as shown in the bar graph (Figure 6F). The gene discussed is CCND1; the disease is colorectal carcinoma.