In the present study, the scaffold hopping of quinoline (C9H7N) (and the FDA-approved multitargeted receptor tyrosine kinase (RTK) inhibitor sunitinib[(Z)-N-(2-(diethylamino) ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene) methyl)-2,4 dimethyl-1H-pyrrole-3-carboxamide), which was also demonstrated to inhibit GIST [59,98,99,100,101,102], led to the discovery of NSC772864 (9-chloro-6-((2-(diethylamino) ethyl) amino)-11H-indeno[1,2-c] quinolin-11-one), a newly synthesized small molecule from our lab (Figure 7). Here, NTRK1 is linked to gastrointestinal stromal tumor.