In our cardiomyopathy series, three novel heterozygous TMPO variants (c.1184del_p.(Gly395Glufs*11), c.370C>T_p.(Leu124Phe) and c.718G>A_p.(Ala240Thr), were identified in 6/5000 patients belonging to five unrelated families, in the absence of other disease-causing variants in the major CM genes [26] and in exome sequencing in some of them. The gene discussed is TMPO; the disease is cardiomyopathy.