Taylor et al. who described TMPO p.(Arg690Cys) assumed this variant could cause DCM based on the evaluation of only one function (interaction of LAP2α p.(Arg690Cys) with the lamin A/C terminus) [21], although it is now known that this is a frequent and functional polymorphism in Latin America, and may be considered as a modifier gene [45,46]. This evidence concerns the gene TMPO and familial dilated cardiomyopathy.