First, we demonstrated that inhibition of PTPN1 decreases BMPR2 expression and signaling and induces endothelial dysfunction; however, it would be important to see whether the opposite is true as well: whether overexpression of PTPN1 activates BMPR2 signaling and reverses abnormal endothelial cell behaviors. This evidence concerns the gene BMPR2 and endothelial dysfunction.