CALR and breast cancer: In the current study, we further described and quantified the cellular mechanism of action of panobinostat in breast cancer, including that (i) only about 10% of CSCs died from drug exposure; (ii) 42% expressed the “eat me” signal, calreticulin; and (iii) myeloid cells are prone to be licensed but are present in limited amounts compared to the total CSCs in their niche.