In the current study, we further described and quantified the cellular mechanism of action of panobinostat in breast cancer, including that (i) only about 10% of CSCs died from drug exposure; (ii) 42% expressed the “eat me” signal, calreticulin; and (iii) myeloid cells are prone to be licensed but are present in limited amounts compared to the total CSCs in their niche. This evidence concerns the gene CALR and breast carcinoma.