A recent work by Stalke et al. has shown that, in 6 pediatric patients harboring KIF12 variants, cholestasis may be due to a perturbed polarization of hepatocytes, which leads to an incorrect positioning of the hepatocanalicular membrane of channel proteins, such as ATP binding cassette subfamily B member (ABCB) 4 and ABCB11, regulating the transport and extrusion of bile salts into the bile canaliculus [69]. The gene discussed is KIF12; the disease is cholestasis.