We previously reported that downregulation of two miRNAs, miR-128 and miR-148a, additively alters their target KLF4 via extensive overlapping of target sites, leading to enhancement of the inflammatory responses in plasmacytoid dendritic cells in the systemic lupus erythematosus (SLE) mouse model [100]. This evidence concerns the gene KLF4 and systemic lupus erythematosus.