In order to investigate whether the CA IX inhibitor was capable of potentiating the effect of Cis-Pt on tumor cells in an endothelial-like phenotype, TNBC cells were plated on Matrigel, grown in hypoxia in the presence of CM-MSCs and treated with SLC-0111 (100 μM), Cis-Pt (1 μM) and a combination of the two drugs for 24 h. This evidence concerns the gene CA9 and neoplasm.