For further analysis, merging expression patterns revealed distinct TME subpopulation with a high abundance of VEGFA, CTNNB1, MMP7, and CD44 in regulatory T cells, mast cells, macrophages, myeloid cells; a low expression level of CD4+Tc and CD8+Tc cells; and exhausted CD8 T cells with the TME of CRC patients (Figure 9B–E). This evidence concerns the gene CD4 and colorectal carcinoma.