Herein, we explored publicly available scRNA-seq datasets of CRC and found a high abundance of VEGFA, CTNNB1, MMP7, and CD44 in regulatory T cells, mast cells, macrophages, and myeloid cells; a low expression level of CD4+Tc and CD8+Tc cells; and exhausted CD8 T cells with the TME of CRC patients, suggesting its associates with the immune landscape of CRC based on similarities with the control. Here, CD8A is linked to colorectal carcinoma.