VEGFA and colorectal carcinoma: Moreover, the activation of the signal transducer and activator of transcription-3 (STAT3), a member of the STAT family of transcription factors, which modulates various biological processes and is an attractive treatment target in CRC [31], was shown to upregulate VEGF-A in primary and metastatic CRC, and signals a poor prognosis [32,33,34,35,36].