Herein, we explored publicly available scRNA-seq datasets of CRC and found a high abundance of VEGFA, CTNNB1, MMP7, and CD44 in regulatory T cells, mast cells, macrophages, and myeloid cells; a low expression level of CD4+Tc and CD8+Tc cells; and exhausted CD8 T cells with the TME of CRC patients, suggesting its associates with the immune landscape of CRC based on similarities with the control. This evidence concerns the gene CD4 and colorectal carcinoma.