MMPs are extracellular proteases that target cytokines and receptors [42,43]; moreover, one member of the MMP family (MMP7) is widely overexpressed in approximately 80% of CRC cases, and is associated with tumor neovascularization, invasion, and distant lymph node metastasis [44,45,46,47,48,49]. This evidence concerns the gene MMP7 and neoplasm.