DCs in the tumor-draining lymph nodes have been shown to upregulate PD-L1 expression upon ingestion of apoptotic tumor cells, which similarly results in decreased T-cell induction [65], but when PD-L1 is deleted in DCs, tumor growth is restricted as a result, and antitumor CD8+ T-cell responses are enhanced [66]. This evidence concerns the gene CD8A and neoplasm.