ESM1 and acute respiratory distress syndrome: However, several issues can be raised: (1) there was a variable diffusion (at equal loaded amounts, blood endocan levels vary from 25 to 116 ng/mL, far greater than values observed in WT mice); (2) we did not measure endocan blood levels beyond Day 0 in the endocan-treated Esm1−/− mice, limiting the interpretability of our results, and (3) this remains a preventive model in which endocan starts to spread before the initiation of experimental ARDS.