The polyphenolic flavone Luteolin has shown the capacity to inhibit microglia activation by reducing the release of inflammatory mediators and alleviate neuroinflammation induced in an in vivo brain hemorrhage model by downregulating TLR-4/TNF receptor-associated factor 6 (TRAF6)/NF-κB signaling [116]. This evidence concerns the gene TRAF6 and intracranial hemorrhage.