APP and Alzheimer disease: Regarding senile Aβ plaques in AD as well, numerous studies prove the efficacy of several flavonoids in reducing Aβ42 aggregation by inhibiting the expression of the enzyme β-secretase (BACE1) responsible for the cleavage of amyloid precursor protein (APP) and the consequent formation of Aβ42 [198,199,200,201,202].