AKT1 and cancer: In recent years, interest in apigenin has grown, especially for its chemopreventive and anti-cancer properties and its capacities to modulate phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt), mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK), nuclear transcription factor-κB (NF-κB), and Wnt/β-catenin pathways, involved in cell proliferation and survival, as well as in the processes of migration and metastasis [68].