APP and major depressive disorder: Gene-set analysis also revealed significant enrichment for the three disorders, the most associated gene ontology (GO) term was negative regulation of amyloid precursor protein catabolic process (13 genes, β(SE) = 2.23(0.26); enrichment p after Bonferroni correction = 2.7 × 10−13) for AD, IgG binding (9 genes, β(SE) = 0.03(0.31); Pbonf = 0.0056) for PD and GABAergic synapse (64 genes, β(SE) = 0.74(0.13); Pbonf = 9.5 × 10−5) for MDD (Table S2; see URLs to access the full list of pathways tested and the genes driving these enrichments).