The most significant associations were detected in some of the most implicated genes in neurodegenerative/neuropsychiatric disorders, namely, APOE (apolipoprotein E, with AD) [39], SNCA (alpha synuclein, with PD) [40] and ZSCAN12 (zinc finger and SCAN domain-containing 12, with MDD) [41]. Here, APOE is linked to major depressive disorder.