Moreover, CLDN1 was described to promote mesenchymal transformation in hepatocellular carcinoma (HCC) by upregulating Slug and Zeb1 [55], and to enhance the invasive ability of oral squamous cell carcinoma by promoting the cleavage of laminin-5 gamma2 chains via MMP-2 and membrane-type MMP-1 [56]. This evidence concerns the gene MMP2 and hepatocellular carcinoma.