Based on the experimental data derived from immunological assays in the plasma samples of COVID-19 patients, elevated levels of key proinflammatory determinants, including different interleukins (ILs), fibroblast growth factor (FGF), interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and vascular endothelial growth factor (VEGF), have become evident. The gene discussed is TNF; the disease is COVID-19.